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Liver Function Tests: So Mysterious, Yet So Important

The liver is the second largest organ in and the serum globulin test.
the human body (only the skin is bigger). Serum albumin is the main protein in
The liver is also one of the most blood plasma. A decrease in the serum
important organs, because it performs albumin level may indicate chronic liver
dozens of tasks that are critical to disease. Serum albumin can also be
human health. Since most liver diseases decreased in other conditions like kidney
cause only mild symptoms in the early disorders and malnutrition.
stages, it's vital to detect these The serum globulin test measures the
diseases early. three types of globulins (globulins
Basically, liver function tests, which contain most of the antibodies of the
are also routinely called "LFTs," assess blood): alpha, beta and gamma. The liver
the overall health and the anatomical synthesizes the first two and the cells
integrity of liver. LFTs include of the immune system synthesize the gamma
measurements of albumin, various liver globulin. In liver disorders, the alpha
enzymes, bilirubin, cholesterol and total and the beta globulin are decreased and
protein. All of these tests can be the gamma globulin levels are
performed at the same time. significantly increased. The normal
Liver function tests are generally albumin globulin ratio is reversed.
divided into four categories. 4) Other tests might include
1) Tests based on the detoxification and ultrasonography and biopsy.
excretory functions. The serum bilirubin Ultrasonography is done as the first test
test is typical. Bilirubin is an for diagnosing obstructive jaundice. It
orange-colored substance in bile produced is also done in cases of gall stone
by the breakdown of red blood cells. When disease and detecting lesions in the
bilirubin levels are high, a condition liver. Along with Doppler, it is used to
called jaundice occurs. Too much assess the condition of the blood
bilirubin is usually due to increased vessels.
destruction of red blood cells Biopsy is done through the skin
(hemolysis) or because the liver can no (sometimes with the ultrasonographic
longer remove bilirubin in a timely guidance) in cases of liver disease of
manner. uncertain cause. Biopsy can also uncover
2) Tests that detect damage to the liver suspected cancers, enlarged liver and
structure. There are a number of enzymes enlarged spleen.
in the liver. Elevated liver enzymes In summary, liver function tests evaluate
indicate that there is damage to the a wide range of normal tasks performed by
liver cells, or that there is an the liver. But a reliable diagnosis also
obstruction to bile flow. depends on a complete history and
3) Tests based on bio-synthetic complete physical examination in addition
functions. These liver function tests to the test themselves.
typically include the serum albumin test




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